177Lu-EDTMP for Treatment of Bone Pain in Patients with Disseminated Skeletal Metastases
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چکیده
منابع مشابه
Comparative Therapeutic Efficacy of 153Sm-EDTMP and 177Lu-EDTMP for Bone Pain Palliation in Patients with Skeletal Metastases: Patients’ Pain Score Analysis and Personalized Dosimetry
INTRODUCTION The aim of the present study was to compare the therapeutic efficacy of 153Sm-EDTMP and 177Lu-EDTMP in pain palliation in cancer patients with skeletal metastases. MATERIALS AND METHODS Thirty patients (25 M:5 F, mean age: 66.0 ± 14.7 years) of breast/prostate cancer with documented skeletal metastases were recruited prospectively. Twenty patients were considered randomly for tre...
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Skeletal metastases or secondary cancerous lesions in bone, are common in patients suffering from breast, lung and prostate cancer, in the advanced stage of the disease. These metastatic lesions in skeleton, often lead to excruciating pain and other related symptoms such as: lack of mobility, neurological deficits, depression, anxiety, anger, fear of death etc., which adversely affect the quali...
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Radionuclide therapy is widely used as an effective modality in the management of bone pain. The main indication for this treatment is symptomatic bone metastases, confirmed by bone scintigraphy. We present a case of small cell lung cancer (SCLC) stage T4N2M1b, with a good metabolic response to systemic therapy and radiotherapy of the primary tumor and locoregional disease, which became metabol...
متن کاملProduction, Quality Control and Pharmacokinetic Studies of 177Lu-EDTMP for Human Bone Pain Palliation Therapy Trials
Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...
متن کاملEffectiveness and complications of 153Sm-EDTMP in palliative treatment of diffuse skeletal metastases
Introduction: The aim of the present study was to evaluate the efficacy and safety profile of bone palliative therapy following administration of 153Sm-EDTMP in patients with intractable metastatic bone pain. Methods: Sixteen patients (9 male, 7 female) aged 29-80 years (57.3±16.7 years) with severe metastasis-related bone pain resistant to analgesic medications were enrolled in the...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine Technology
سال: 2014
ISSN: 0091-4916
DOI: 10.2967/jnmt.113.132266